王中原，理学博士。教授、博导。主要从事发现肿瘤、衰老等生理病理过程中的新机制和新靶点研究，为疾病治疗提供全新的方案和策略。近年来以第一作者或通讯作者在Nature Metabolism、PNAS、Cell Reports、Redox Biology等国际知名学术期刊发表多篇论文。承担多项国家自然科学基金及省部级项目。热忱欢迎对课题组感兴趣的本科生、研究生和博士后加入实验室。
肿瘤发生、发展的机制研究及靶向治疗
衰老的分子机制和干预研究
主持多项国家自然科学基金项目、省部级项目及437437必赢国际网址高层次人才启动经费项目等
Peng L#, Xiang S#, Wang T, Yang M, Duan Y, Ma X, Li S, Yu C, Zhang X, Hu H, Liu Z, Sun J, Sun C, Wang C, Liu B*, Wang Z*, Qian M*. The hepatic clock orchestrates with HIF-1a to coordinate nucleotide availability during liver damage repair. Nature Metabolism, 2025 Jan;7(1):148-165.
Wang K#, Zhang X#, Fan Y, Zhou L, Duan Y, Li S, Sun Z, Zhang C, Yang H, Yuan W, Peng L, Ma X, Xiang S, Wang T, Yang M, Zhang Z, Wang J, Wang Z*, Qian M*. Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. Redox Biology, 2024 Dec;78:103419.
Zhang X#, Duan Y#, Li S, Zhang Z, Peng L, Ma X, Wang T, Xiang S, Chen G, Zhou D, Lu D*, Qian M*, Wang Z*. CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. Cell Reports, 2024 Sep 24;43(9):114662.
Peng L#, Zhou L#, Li H, Zhang X, Li S, Wang K, Yang M, Ma X, Zhang D, Xiang S, Duan Y, Wang T, Sun C, Wang C, Lu D*, Qian M*, Wang Z*. Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity. Cell Reports, 2024 Apr 23;43(4):114003.
Wang Z#, Zhou L#, Wang Y, Peng Q, Li H, Zhang X, Su Z, Song J, Sun Q, Sayed S, Liu S, Lu D*. The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer. Theranostics, 2021, 11(9): 4421-4435.
Wang Z#, Zhou L#, Xiong Y, Yu S, Li H, Fan J, Li F, Su Z, Song J, Sun Q, Liu S, Xia Y, Zhao L, Li S, Guo F, Huang P, Carson D*, Lu D*. Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/TCF complex. Br J Pharmacol, 2019,176(17):3390-3406.
Su Z#, Song J#, Wang Z#, Zhou L, Xia Y, Yu S, Sun Q, Liu S, Zhao L, Li S, Wei L, Carson D*, Lu D*. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci U S A,2018, 115(32): E7522-E7531.
Wang Z#, Li B#, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson D*, Lu D*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A,2016, 113(46): 13150-13155.
